Thursday, 3 November 2016

Breast-Conserving Therapy Versus Radical Mastectomy for Early Breast Cancer

The aim of this clinical study was to compare breast-conserving therapy (BCT) and radical mastectomy (RM) in the treatment of early breast cancer. Materials and methods: From March 1986 to the end of 1989, 117 women with a breast tumor of up to 2 cm in size were included in this study; 66 women had a quadrantectomy, while 51 had a radical mastectomy.

Early Breast Cancer
Full axillary dissection was performed in all patients, while adjuvant chemotherapy with cyclophosphamide, methotrexate and fluorouracil was conducted in node-positive patients. Radiation to the remaining breast parenchyma consisted of external-beam therapy, with or without regional irradiation, without boost to the tumor bed. Results: The follow-up of patients in the two treatment groups was limited to 240 months.

The mean period of observation (SD±) was 201.34 months (54.12 ± 226.5) for the patients with breast-conserving therapy (BCT) and 195.84 months (35.1 ± 226.5) for the patients with radical mastectomy.

Monday, 24 October 2016

Multiple Myeloma, A Patient with Multiple Infections

We report a case of a 63-year-old male with recurrent severe respiratory infections during the last year. During the last 6 months, he presented with a gradual onset of generalized weakness, fatigue, myalgia and anorexia. He self-medicated with intramuscular analgesics developing abscess of the left gluteal area.

Multiple Myeloma
Throughout his hospitalization, anemia and kidney failure were found without apparent cause. Wide antibiotic coverage was used without signs of improvement. The patient was transferred to the University Hospital, where under the criteria of recurrent infections, normocytic anemia, and kidney failure; metastatic series imaging is sent.


The finding of lytic punched out lesions in the skull X ray suggested multiple myeloma. Multiple Myeloma represents pathology of diverse distribution. Although, the incidence is not reported in Honduras, we consider it an underdiagnosed pathology often missed because it is not considered by clinicians.